Nutritional
Support for Bone Health*
PRODUCT IS A MIXTURE OF
Calcium Citrate, Calcium Carbonate, Calcium Stearate, Magnesium Citrate,
Magnesium Glycinate.
PRODUCT DISCUSSION
Calcium is the major mineral responsible for the health of the body’s bones
and teeth. Calcium intake is critical to achieving peak bone mass, maintaining
muscle contractions, nerve impulses and supporting heart health. This unique
formula contains Calcium Citrate, one of the most bioavailable sources of
Calcium, with chelated Magnesium for additional support of bone health.*
STRUCTURE AND FUNCTION
Calcium is an essential nutrient compromising 2% of adult body weight. More
than 99% of the body’s Calcium is found in the skeleton, representing 25% of
the dry weight of bones. Calcium reacts with phosphoric acid to form insoluble
salts whose primary function is to provide rigidity to the skeleton. In
addition, the Calcium salts are required to maintain a critical Calcium
concentration in extra-cellular water, which is necessary for support of the
heart, neuromuscular system, and enzymatic reactions.*
Bone is a dynamic tissue, going through a continuous process of formation
and absorption. Calcium accumulates in the skeleton during childhood until
maturity when equilibrium is reached. During midlife the body acquires the
Calcium it needs by slowly absorbing bone. Adequate Calcium intake during
adolescence and adulthood is crucial to achieve optimal bone mass.*
Many factors contribute to the development of osteoporosis including sex,
race, age, and hormonal status. Even your body type, family history, Calcium
intake, and how often you exercise can have an impact. Some populations,
especially Caucasian women of northern European ancestry and Asian women in
their bone forming years (teens and young adults) have a higher risk of
developing osteoporosis. Women going through menopause, those with a family
history of the disease and the elderly are also at a higher risk. American
women of African heritage have the lowest incidence of osteoporotic fracture.
It’s important to remember that everyone loses bone mass with age. Regular
exercise, a healthy diet and adequate Calcium intake helps maintain good bone
health and may reduce the high risk of osteoporosis later in life, especially
for teens and young adult Caucasian and Asian women. A total dietary intake
above 2,000 mg has no further known benefit to bone health.
Magnesium also plays an important role in bone health. The human skeleton
utilizes 55% of the body’s Magnesium. Magnesium aids in the absorption of
Calcium by promoting the secretion of calcitonin, a hormone that aids in the
influx of calcium into bone. In addition, Magnesium modulates the secretion of
parathyroid hormone, whose function is to draw Calcium out of bones and
deposit it in soft tissue.*
INDICATIONS
Adequate Calcium intake during adolescence, adulthood and menopause is crucial
to achieve and maintain peak bone mass. According to the Third National Health
and Nutrition Examination Survey (NHANES III), more than 50% of children,
adults, and elderly Americans’ dietary Calcium intakes fail to meet
recommended levels. In addition, certain regularly prescribed drugs may cause
Calcium and/or Magnesium depletions. PhysioLogics’ Calsorb® may be a
desirable dietary supplement for clients who want to promote bone mass and
support overall bone health.*
HOW CLIENTS MAY BENEFIT
- Primary support of bone health begins during adolescence when the
skeleton is accruing its peak mass. The Food and Nutrition Board of the
Institute of Medicine issued a Dietary Reference Intake for Calcium to
1,300 mg per day for 9 to 18 year old girls, and 1000 mg for 19 to 50 year
old women. Calcium supplementation during these formative years may
contribute to bone density in the future.*
- Optimize peak bone mass during all stages of life for a strong skeletal
system in both men and women.*
- Provide extra Calcium normally obtained from bones required for proper
muscle contraction and nerve function.*
- Magnesium aids in the absorption of Calcium into bone and is essential
to maintain proper bone mineralization.*
- NIAMS, a branch of the National Institutes of Health, recently completed
a placebo-controlled double blind study evaluating the effect of Calcium
supplementation on bone mass accretion over 7 years in a group of 354
prepubescent females. The results will provide data about the efficacy of
Calcium supplementation with regard to bone mass, circulatory health, and
weight control.
- A study of 12 young healthy men found that daily supplementation with 15
mmol (365mg) Magnesium supports bone health, as measured by reduced levels
of resorption biochemical markers.
CLINICAL EVIDENCE
- A French study shows that Calcium and Vitamin D supplementation may not
only promote bone health, but may also increase bone mass. Over 3,000
women over the age of 69 received 1.2 grams of calcium and 800 IU of
Vitamin D or a placebo every day for 18 months. Not only did 43% of the
supplemented women have stronger bones, but bone density increased
slightly in this group as well.
- A meta-analysis of four well-designed intervention studies concludes
that Calcium supplementation of ~1000 mg/d in women can promote bone
health in every bone except the ulna.
- A placebo-controlled double-blind study of 389 men and women over 65
years old found a significant positive change in bone density in patients
that consumed 500 mg Calcium and 700 IU Vitamin D for 3 years versus the
placebo group.
SUMMARY
Calcium and Magnesium are essential nutrients for bone formation and
maintenance. PhysioLogics’ Calsorb® combines Calcium and Magnesium in a
highly absorbable form for those who want to ensure they obtain adequate
amounts of these minerals to support bone health through all stages of life.*
SUGGESTED DOSAGE
For adults, take three (3) caplets one to two times per day, preferably with a
meal, or follow the advice of your health care professional. As a reminder,
discuss the supplements and medications you take with your health care
providers.
REFERENCES
Alaimo K, McDowell MA, Briefel RR, Bischof AM, Caughman CR, Loria CM,
Johnson CL. Dietary intake of vitamins, minerals, and fiber of persons ages
2 months and over in the United States: Third National Health and Nutrition
Examination Survey, Phase 1, 1988-91. Adv Data. 1994 Nov 14;(258):1-28.
Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD,
Meunier PJ. Vitamin D3 and calcium to prevent hip fractures in the elderly
women. N Engl J Med. 1992 Dec 3;327(23):1637-42
Dawson-Hughs B. Osteoporosis treatment and the calcium requirement. Am J
Clin Nutr. 1998. 67 (1):5-6. Dawson-Hughes B, Harris SS, Krall EA, Dallal
GE. Effect of calcium and vitamin D supplementation on bone density in men
and women 65 years of age or older. N Engl J Med. 1997 Sep 4;337(10):670-6.
Dimai HP, Porta S, Wirnsberger G, Lindschinger M, Pamperl I, Dobnig H,
Wilders-Truschnig M, Lau KH. Daily oral magnesium supplementation suppresses
bone turnover in young adult males. J Clin Endocrinol Metab. 1998
Aug;83(8):2742-8.
DRI for Calcium, Phosphorues, Magnesium, Vitamin D, and Fluoride.
Institute of Medicine. CH 4. Calcium. Pp71-91 Ferment O, Touitou Y.
Magnesium: metabolism and hormonal regulation in different species. Comp
Biochem Physiol A. 1985;82(4):753-8.
Institute of Medicine. Food and Nutrition Board. Dietary Reference
Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. National
Academy Press. Washington, DC, 1999.
Matkovic V. Nutrition, genetics and skeletal development. J Am Coll Nutr.
1996. 15(6):556-69
NIH consensus development panel on optimum calcium intake. JAMA. 1994.
272(24):1942-8
Rude RK and Olerich M. Magnesium deficiency: Possible role in
osteoporosis associated with gluten-sensitive enteropathy. Osteoporos Int
1996;6:453-61.
Welten D, Kemper H ,Post G, Van Staveren W. A metaanalysis of the effect
of calcium intake on bone mass in young and middle aged females and males. J
Nutr. 1995 Nov;125(11):2802-13
= Vegetarian Formula |
